For much of his adult life, Robert Helms worked as a professional medical test subject. He chronicled his experiences, and that of others, in his zine Guinea Pig Zero. Excerpts of the publication are available in the book Guinea Pig Zero: An Anthology of the Journal for Human Research Subjects. “When I rent my healthy body to medical science, I am the temporary employee of a research team, paid as a contractor for each job. I do my bleeding, pissing work in a blurry area between patient and subject.  This blurry area has made for intense public debate, and the questions relating to the guinea pig as a worker are not even considered by lawmakers in this country (yet they are in Canada or France)." We spoke to Helms about his career choice, the day to day lives of professional guinea pigs, and the role of human test subjects in modern medical science.