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| Largest Share Gains in 2009 | ||
| Vanda Pharmaceuticals | VNDA | 2063.46% |
| OncoGenex Pharmaceuticals | OGXI | 1788.14% |
| Human Genome Sciences | HGSI | 1356.19% |
| Compugen | CGEN | 1054.76% |
| Keryx Biopharmaceuticals | KERX | 1036.36% |
| Opexa Therapeutics | OPXA | 900.00% |
| Athersys | ATHX | 797.83% |
| Cell Therapeutics | CTIC | 714.29% |
| Oncothyreon Inc | ONTY | 582.28% |
| Raptor Pharmaceutical | RPTP | 577.78% |
Largest Share Drops in 2009 |
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| Repros Therapeutics | RPRX | -92.45% |
| Sequenom | SQNM | -79.20% |
| GTx | GTXI | -75.64% |
| Matrixx Initiatives | MTXX | -74.30% |
| AspenBio Pharma | APPY | -71.33% |
| MiddleBrook Pharmaceuticals | MBRK | -66.00% |
| Catalyst Pharmaceutical | CPRX | -65.95% |
| Idenix Pharmaceuticals | IDIX | -63.12% |
| Osiris Therapeutics | OSIR | -62.62% |
| Verenium Corp | VRNM | -57.39% |
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