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DEALS

Pushing into China

Swiss biopharma Nycomed buys major stake in Chinese firm.

MARIE DAGHLIAN

The Burrill Report

Two deals this week signify the increasing importance of the Chinese healthcare market for biopharmaceutical companies. Swiss biopharma Nycomed acquired 51 percent of Guangdong Techpool Bio-Pharma for $210 million, significantly expanding its presence in China.
 
Nycomed gains access to a fast-growing manufacturer of biologic and protein-based drugs with international potential and a commercialization base for Nycomed products in China. “Techpool's specialty franchise is highly complementary to Nycomed's development strategy and will become a cornerstone of our international expansion in emerging markets,” says Hakan Bjorklund, CEO of Nycomed.
 
Techpool specializes in the research, development, manufacturing and marketing of biologic drugs derived from natural sources. Techpool's products are sold across China and exported to a number of countries and regions, including Japan and South Korea. The company has also built a strong intellectual property position, with 35 patents filed, of which 17 have already been granted, including one U.S. patent approval. Shanghai Pharmaceutical Group, a leading Chinese pharmaceutical conglomerate, holds 41 percent of the shares of Techpool and has previously been the majority shareholder.
 
The second China-focused deal involves a partnership between Simcere Pharmaceutical Group and Bristol-Myers Squibb to co-develop a preclinical therapeutic for the treatment of cancer. Under the terms of their agreement, Simcere will have exclusive rights to develop and commercialize BMS-817378, a small molecule MET/VEGFR-2 inhibitor, in China while Bristol-Myers will retain exclusive rights in all other markets. The partners will determine the strategic development together, which will initially be conducted by Simcere. Financial terms were not disclosed.
 
The partnership represents a creative approach to accelerate a preclinical oncology compound to clinical proof-of-concept by leveraging the complementary strengths of a Chinese pharmaceutical company and a global pharmaceutical company, according to Bristol-Myers.

Simcere Pharmaceutical Group specializes in the development, manufacturing, and marketing of branded generic and proprietary pharmaceuticals in China. Its shares are traded on the New York Stock Exchange.
 
McKesson’s acquisition of US Oncology was the biggest deal of the week, valued at $2.2 billion, including the assumption of debt. McKesson, a healthcare services and information technology provider, will purchase all outstanding shares of US Oncology, an integrated oncology company, for cash. The deal strengthens McKesson’s solutions offerings in oncology, one of the fastest-growing segments in healthcare. The deal is expected to close by the end of the year.
 
Hungarian pharmaceutical Gedeon Richter acquired the oral contraceptive business of German pharma Grünenthal for $330 million in cash. The deal is a strategic fit for Richter to both strengthen its presence in Western European markets and expand its oral contraceptive product portfolio and follows its recent acquisition of Swiss pharma PregLem. The companies have agreed to complete the technology transfer before late 2012, prior to which Grünenthal will manufacture and supply to Richter the products for all markets.
 
Finally, the biggest funder this week was the U.S. government, awarding more than $1 billion in grants and tax credits to hundreds of small life sciences companies developing new therapies, diagnostics, and medical devices to treat unmet needs; prevent, detect or treat chronic or acute diseases and conditions; reduce the long-term growth of healthcare costs in the United States; or significantly advance the goal of curing cancer within 30 years. A full list of Qualifying Therapeutic Discover Project grant and credit recipients is available here.  


DEALS FOR THE WEEK ENDING NOVEMBER 5
Global Venture Financings
Company Location Amount Raised (USD M) Principal Focus
Intersect ENT Palo Alto, CA 30.0 Medical devices
Karyopharm Therapeutics Newton, MA 20.0 Therapeutics
Vascular Pathways Los Altos, CA 14.0 Medical devices
Gene Security Network Redwood City, CA 12.0 Diagnostics
PathCentral Irvine, CA 10.0 Tools/Technology
DiCOM Grid Phoenix, AZ 7.5 Healthcare IT
Virtual Incision Lincoln, NB 2.0 Medical devices
Gynesonics Redwood City, CA 0.5 Medical devices
Hatchtech Parksville, Australia 6.3 Therapeutics--infectious
i-Optics The Hague, the Netherlands 5.9 Diagnostics
NanoTherics United Kingdom 1.8 Tools/Technology
Total Raised US 96.0
Total Raised Non-US 14.0
Grants 
Company Funding/Contracting Agency Amount Raised (USD M) Principal Focus
Various Biotech Companies Qualifying Therapeutic Discovery Project Awards 1,095.5 Therapeutics, diagnostics, medical devices
Great Valley Energy California Energy Commission 2.0 Biofuels from sorghum
GeneNews Malaysian Biotechnology Corp 0.6 Colorectal cancer
Algae Aquaculture Technologies Montana Department of Environmental Quality 0.4 Renewable fuels
Adolor Michael J. Fox Foundation 0.4 Parkinson's 
Total Grants 1,098.9
PUBLIC FINANCINGS
Company Ticker Amount
Raised (USD M)
Financing Type
iBio OTC:IBPM 6.0 PIPE
International Isotopes OTC:INIS 5.8 PIPE
CardioGenics (Canada) OTC:CGNH 1.9 PIPE
Miraculins (Canada) TSX-V:MOM 1.0 PIPE
Kane Biotech (Canada) TSX-V:KNE 0.2 PIPE
MAKO Surgical MAKO 53.1 Follow on
Dynavax Technologies DVAX 42.0 Follow on
GTx GTXI 40.0 Follow on
PDL BioPharma PDLI 88.0 Debt
ThromboGenics Euronext:THR 3.9 Warrant exercise
Allon Therapeutics TSX: NPC 10.0 Convertible royalty and revenue obligation
Stem Cell Therapeutics TSX-V:SSS 1.8 Warrant exercise
BioTime BTX 24.2 Warrant exercise
Marina Biotech MRNA 3.3 Securities Purchase Agreement
TOTAL PUBLIC FINANCINGS-US 262.4
 NON-US 18.8
M&A 
Acquirer Target Deal Value
(USD M)
Focus
McKesson US Oncology 2,200.0 Integrated oncology services
Gedeon Richter (Hungary) Grunenthal's contraceptive business (Germany) 329.8 Women's health
Nycomed (Switzerland) Guangdong Techpool Bio-Pharma (China) 210.0 Biopharmaceuticals
Warburg, Pincus Ventures Thoratec's ITC division 55.0 Point-of-care testing
Cambrex Zenara Pharma (India) 20.0 Pharmaceuticals
GE Healthcare Orbotech Medical Solutions 14.0 Medical technology
NeoPharm Insys Therapeutics N/A Pain and oncology
IDEX Corporation The Fitzpatrick Company N/A Tools/Technology
Hanmax Investment (China) Tongjitang Chinese Medicines (China) N/A Musculoskeletal, neurology, dermatology
Life Technologies Labindia (India) N/A Tools/Technology
Alliances 
Company/Licensee Company/Licenser Deal Value
(USD M)
Focus
Amgen Nektar Therapeutics 50.0 Drug ingredients supply agreement
AOP Orphan Pharmaceuticals (Austria) Shield Holdings 4.3 Anemia drug license
454 Life Sciences (Roche-Switzerland) DNA Electronics N/A DNA sequencing partnership
Quiltiles GmbH (Germany) Dako (Denmark) N/A Personalized medicine alliance
Daiichi Sankyo (Japan) AstraZeneca (United Kingdom) N/A Heartburn drug co-promotion
Life Technologies BGI (Beijing Genomics Institute-China) N/A Genomic sequencing partnership
BASF Plant Science (Germany) Precision BioSciences N/A Crop traits technology license
Valeant Pharmaceuticals (Canada) Kadmon Pharmaceuticals N/A Hepatitis C drug license
Kadmon Pharmaceuticals Valeant Pharmaceuticals (Canada) N/A Hepatitis C drug license
Dow AgroSciences Viamet Pharmaceuticals N/A Crop protection technology alliance
Bayer CropScience (Germany) SentiSearch N/A Infectious disease collaboration
Bristol-Myers Squibb Simcere Pharmaceutical (China) N/A Cancer therapeutics partnership
Fibrocell Science Hefei Meifu Bio-Tech (China) N/A Stem cell therapeutics joint venture
US Navy Cobalt Technologies N/A Renewable fuels partnership
Cellectis (France) Japan Tobacco (Japan) N/A Crop traits technology license
bioMerieux (France) Biocartis (Switzerland) N/A Diagnostics partnership
Sweden Orphan Biovitrum (Sweden) Rechon Life Science (Dongbao-China) N/A Anemia drug license


November 05, 2010
http://www.burrillreport.com/article-pushing_into_china.html

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